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europa    seventh

12 February 2019

In a recently published paper in Food and Chemical Toxicology Van der Voet et.al.  fully explain the graphical difference and equivalence tests, and apply them to a.o. a G-TwYST example.


Equivalence limit scaled differences for untargeted safety assessments: Comparative analyses to guard against unintended effects on the environment or human health of genetically modified maize

Hilko van der Voet, Paul Goedhart, Esteban Garcia-Ruiz, Conceptíon Escorial, Jana Tulinská


Equivalence tests have been used to show absence of unintended effects of genetically modified maize lines. The authors propose a graphical method to overview equivalence tests for up to e.g. 100 of endpoints. One example considers arthropod counts in a maize field over three years and supports environmental safety assessment. A second example considers rat feeding study data from G-TwYST and supports human health safety assessment. The authors claim that proposed scaling performs better for displaying equivalence test results than traditional Standardised Effect Sizes.


The full paper is available here.

 Graphical abstract