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The experimental test groups chosen and the minimum number of animals per group to be used are shown in the following table:

Group

% of daily dietary intake (w/w)

No. of animals

Isogenic non-
GM (NK603)

NK603

NK603 +
Roundup

Males

Females

1

33

0

0

16

16

2

22

11

0

16

16

3

0

33

0

16

16

4

22

0

11

16

16

5

0

0

33

16

16

Total

 

80

80

 

The number of animals per group has been chosen based on the OECD Test Guideline 408 and as recommended by the EFSA Guidance (2011).

 

A statistical analysis will be performed prior to the beginning of the feeding trial to determine whether the number of animals per group chosen is adequate, and, if necessary, it will be adjusted. The data to be obtained will be compared with background data on variations in endpoint values for Wistar Han Rcc rats fed a standard lab chow from Harlan Inc. present in the public domain (http://webapps.harlan.com/wistarhannover).

 

A statistical analysis of the data obtained will be performed by WP4 by taking into account, among other documents, the EFSA Guidance (2011) and will be accompanied by an analysis report. A specific chapter on assumptions and uncertainties will be included in the study report.

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G-TwYST Interim Report available

15 February 2017

 

The G-TwSYT team completed a publicly available Interim report with information about the progress that has been made in the first 1.5 years of the project. The report can be downloaded here.

Value and pitfalls of stakeholderconsultation

17 January 2017

 

In 2013 the Dutch Commission on Genetic Modification (COGEM) published a topic report on alarming studies on the safety of GMOs. COGEM pointed out that while repetition of ‘alarming studies’ is sometimes the only way to reject or confirm the results, stakeholder participation during investigation may increase its social robustness.

In a letter sent to the Secretary of State of Infrastucture and Environment on January 11, 2017 COGEM adds some reflections on the value and possible pitfalls of stakeholder participation based on experiences in and results of the GRACE project.

The COGEM letter states that the involvement of stakeholders in this project has been meticulous and transparent and has finally contributed to the validity of the results also from a broader social perspective. However, COGEM also noticed that some stakeholders were too fixated on their own arguments and vision, that reflection and interaction became difficult. According to COGEM this situation significantly hampered the achievement of broadly supported conclusions. On the basis of this experience COGEM also proposed some guidelines for improving such processes.

 

Read the full letter >

Scientific quality criteria (2)

28 November 2016

 

So far, we have received comments on the proposed scientific quality criteria from the Federal Office of Consumer Protection and Food Safety, Germany (BVL) on October 5th, 2016. The comments can be downloaded here.

 

The G-TwYST research team responded to the BVL comments on November 28th, 2016. The response can be downloaded here.